文献类型：期刊文献

英文题名：The Hypolipidemic Effect of Dalbergia odorifera T. C. Chen Leaf Extract on Hyperlipidemic Rats and Its Mechanism Investigation Based on Network Pharmacology

作者：Mei, Hui[1] Hu, Huiming[2] Lv, Yanni[3] Ma, Guangqiang[4] Tang, Fangrui[4] Hong, Zhou[5] Shao, Feng[1]

第一作者：Mei, Hui

通信作者：Shao, F[1]

机构：[1]Jiangxi Univ Chinese Med, Key Lab Modern Preparat Tradit Chinese Med, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China;[2]Nanchang Med Coll, Sch Pharm, Nanchang 330004, Jiangxi, Peoples R China;[3]Nanchang Univ, Dept Pharm, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China;[4]Jiangxi Univ Chinese Med, Coll Basic Med, Nanchang 330004, Jiangxi, Peoples R China;[5]Chinese Acad Forestry, Res Inst Trop Forestry, Guangzhou 510520, Peoples R China

年份：2021

卷号：2021

外文期刊名：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000741800600001)】；

语种：英文

摘要：Objective. The aim of this study was to explore the hypolipidemic effect and mechanism of Dalbergia odorifera T. C. Chen leaf extract. Methods. The hypolipidemic effect of D. odorifera leaf extract was investigated using a hyperlipidemic rat model. Then, its mechanism was predicted using network pharmacology methods and verified using western blotting. Results. Compared with the levels in the model group, the serum levels of triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas the serum level of high-density lipoprotein cholesterol (HDL-C) increased dramatically after treatment with the extract. The degrees of hepatocyte steatosis and inflammatory infiltration were markedly attenuated in vivo. Then, its hyperlipidemic mechanism was predicted using network pharmacology-based analysis. Thirty-five key targets, including sterol regulatory element-binding protein cleavage-activating protein (SCAP), sterol regulatory element-binding protein-2 (SREBP-2), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), low-density lipoprotein receptor (LDLR), and ten signaling pathways, were associated with hyperlipidemia. Finally, it was verified that the extract downregulated the protein levels of SCAP, SREBP-2, and HMGCR, and upregulated protein levels of LDLR. Conclusion. These findings provided additional evidence of the hypolipidemic effect of D. odorifera leaf extract.