文献类型：期刊文献

英文题名：Hybrid Fe3O4-Poly(acrylic acid) Nanogels for Theranostic Cancer Treatment

作者：Chen, Ying[1] Nan, Jingya[1] Lu, Yue[2,3,4,5] Wang, Chunpeng[1] Chu, Fuxiang[1] Gu, Zhen[2,3,4,5]

第一作者：陈莹

通信作者：Chen, Y[1]|[a0005125116bcee0aa95c]陈莹;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China;[2]Univ N Carolina, Joint Dept Biomed Engn, Raleigh, NC 27695 USA;[3]N Carolina State Univ, Raleigh, NC 27695 USA;[4]Univ N Carolina, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA;[5]Univ N Carolina, Eshelman Sch Pharm, Mol Pharmaceut Div, Chapel Hill, NC 27599 USA

年份：2015

卷号：11

期号：5

起止页码：771-779

外文期刊名：JOURNAL OF BIOMEDICAL NANOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000344969800002)】；

基金：This work was supported by grant 550KR51307 from NC TraCS, NIH's Clinical and Translational Science Awards (CTSA, NIH) at UNC-CH and the NC State Faculty Research and Professional Development Award to Zhen Gu, and the Natural Science Foundation of China (NSFC) 31100427 and Jiangsu Province Natural Science Foundation BK20131071 to Ying Chen.

语种：英文

外文关键词：Hybrid Magnetic Nanogels; In Situ Co-Precipitation; MRI Imaging; High Drug Loading Capacity; Tumor Target

摘要：Multifunctional nanomedicine integrated with both therapy and diagnostics holds vast potential in cancer treatment. We developed hybrid Fe3O4-poly(acrylic acid) (PAA) nanogels for both drug delivery and magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 nanoparticles were encapsulated inside porous PAA nanogels via an in situ co-precipitation approach. With successive growth of magnetic nanoparticles, the highest magnetization saturation (Ms) value of the Fe3O4 nanoparticles in the PAA nanogels was determined as 20 emu/g. The resulting hybrid Fe3O4-PAA nanogels showed high drug loading capacity (98%) and sustained drug release in vitro. Cytotoxicity assays and cellular imaging demonstrated that the hybrid nanogels were highly biocompatible and efficiently internalized in human neuroblastoma SH-SY5Y cells. In MRI studies, the hybrid nanogels exhibited an excellent contrast in T-2 weighted imaging and a high MRI sensitivity in the tumor site.