文献类型：期刊文献

中文题名：松香基聚丙烯酰胺水凝胶的药物释放性能及其动力学研究

英文题名：Drug Release and Kinetics Properties of Rosin-based Polyacrylamide Hydrogels

作者：张海波[1,2] 蒋建新[2] 高宏[1] 商士斌[1] 宋湛谦[1]

第一作者：张海波

机构：[1]中国林业科学研究院林产化学工业研究所;[2]生物质化学利用国家工程实验室;[3]国家林业局林产化学工程重点开放性实验室:江苏省生物质能源与材料重点实验室,江苏南京210042;[2]北京林业大学材料科学与技术学院,北京100083

年份：2018

卷号：38

期号：3

起止页码：25-32

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

基金：国家自然科学基金资助项目(31470597); 中国林科院林产化学工业研究所研究团队建设创新工程项目资助(LHSXKQ1)

语种：中文

中文关键词：松香;水凝胶;溶胀;药物释放;动力学

外文关键词：rosin;hydrogels;swelling;drug release;kinetics

分类号：TQ35

摘要：以双氯芬酸钠、环丙沙星、茶碱为模型药,研究了松香基聚丙烯酰胺水凝胶的药物释放性能及其释放动力学,结果显示:水凝胶的平衡溶胀率随着松香基交联剂FPA-PEG200-AC用量增加而减小,在pH值7.4磷酸缓冲溶液中最大(12 g/g),去离子水中次之,pH值1.4盐酸溶液中最小;FPA-PEG200-AC用量为0.020 g/mL时,水凝胶对药物负载率最大(10.7%~16.6%)。不同交联剂用量制备的水凝胶的药物释放性能研究结果显示:双氯芬酸钠释放主要集中在1 h内,在3 h内累计释放率基本达到最大值;环丙沙星释放缓慢,8 h后累计释放率达到最大,FPA-PEG200-AC添加量为0.025 g/mL制备的水凝胶对环丙沙星的累计释放率最大,约为99.7%,茶碱在pH值7.4磷酸缓冲液中最大累计释放率均可达到99%,比在pH值1.4盐酸溶液中的累计释放率高。水凝胶的释放动力学模型主要为Higuchi模型(r^2为0.873~0.999)和Korsmeyer-Peppas模型(r^2为0.887~0.999,扩散指数n<0.5,为Fick扩散);当FPA-PEG200-AC用量为0.020、0.030 g/mL时,水凝胶对3种药物的释放机理均为Higuchi模型。
Diclofenac sodium,ciprofloxacin and theophylline were used as model drugs to study the drug release properties and kinetics of rosin-based polyacrylamide hydrogels. The results indicated that the equilibrium swelling ratios of hydrogels decreased with the increase of the amount of rosin-based cross-linking agent FPA-PEG200-AC. And the equilibrium swelling ratio was largest（ 12 g/g） in the pH 7. 4 PBS buffer solution,followed by the deionized water and it was the smallest in the pH 1. 4 hydrochloric acid solution. The drug release properties of hydrogels prepared with different amounts of cross-linking agent showed that the diclofenac sodium was mainly released within 1 h,and reached the maximum values of cumulative release within 3 h. Theciprofloxacin was released slowly and reached the maximum values of cumulative release within 8 h; when the amount of FPA-PEG200-ACwas 0.025 g/mL in hydrogel,the maximum values of cumulative release was about 99.7%. The maximum values of theophylline release in pH 7. 4 PBS buffer could reach 99%,which was higher than the cumulative release rate in pH 1. 4 hydrochloric acid solution. The drug release data of hydrogels were fitted into Higuchi models（ r^2= 0.873-0.999） and KorsmeyerPeppas models（ r^2= 0. 887-0. 999,the diffusional exponent n 0. 5,Fick diffusion）; the drug release of hydrogels was best explained by Higuchi models when the dosage of FPA-PEG200-AC was 0.020 and 0.030 g/mL.