文献类型：期刊文献

英文题名：Synthesis of 2-Hydroxypropyl Dimethylbenzylammonium N,O-(2-carboxyethyl) Chitosan Chloride and Its Antibacterial Activity

作者：Cai, Zhao-Sheng[1,2,3] Song, Zhan-Qian[1,2] Yang, Chun-Sheng[3] Shang, Shi-Bin[1,2] Yin, Yan-Bai[1,2]

第一作者：Cai, Zhao-Sheng

通信作者：Song, ZQ[1]

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu Prov, Peoples R China;[2]SFA, Key & Open Lab Forest Chem Engn, Nanjing 210042, Jiangsu Prov, Peoples R China;[3]Yancheng Inst Technol, Sch Chem & Biol Engn, Yancheng, Jiangsu Prov, Peoples R China

年份：2009

卷号：111

期号：6

起止页码：3010-3015

外文期刊名：JOURNAL OF APPLIED POLYMER SCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000262685000043)】；

基金：Contract grant sponsor: National Natural Science Foundation of China; contract grant number: 30471362.r Contract grant sponsors: Nanjing University, China Pharmaceutical University.

语种：英文

外文关键词：biological applications of polymers; polysaccharides; chemical modification; synthesis; water-soluble polymers

摘要：N,O-(2-carboxyethyl)chitosan (N,O-2-CEC) was prepared from chitosan with 3-chloropropionic acid as modifying agent and NaOH as binding-acid agent. 2-Hydroxypropyl dimethylbenzylammonium N,O-(2-carboxyethyl) chitosan chloride (HPDMBA-CEC) was obtained by the reaction of N,O-2-CEC with glycidyl dimethyl benzyl ammonium chloride (GDMBA) using NaOH as catalyst. The structures of chitosan derivatives were characterized by FTIR, H-1 NMR, and gel permeation chromatography. The antimicrobial activity of HPDMBA-CEC was evaluated against a Gram-negative bacterium Escherichia coli (E.coli) and a Gram-positive bacterium Staphylococcus aureus (S. aureus). Compared with CTS, N,O-2-CEC, and HPDMBA-CTS, HPDMBA-CEC had much stronger antimicrobial activity, and this activity increased with increasing substitution degree of quaternary ammonium group (DQ). When the substitution degree of carboxyethylation (DS of CE) was 0.72 and DQ was 0.60, the minimum inhibitory concentrations (MICs) of HPDMBA-CEC were 3.1 and 6.3 mu g/mL against S. aureus and E. coli, respectively. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 3010-3015,2009