文献类型：期刊文献

英文题名：Effects of Lignin-Based Hollow Nanoparticle Structure on the Loading and Release Behavior of Doxorubicin

作者：Zhou, Yu[1,2] Han, Yanming[1] Li, Gaiyun[1] Chu, Fuxiang[1]

第一作者：周宇;Zhou, Yu

通信作者：Han, YM[1];Chu, FX[1]|[a0005728d87cb2daf502d]储富祥;

机构：[1]Chinese Acad Forestry, Res Inst Wood Ind, Xiangshan Rd, Beijing 100089, Peoples R China;[2]Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224051, Peoples R China

年份：2019

卷号：12

期号：10

外文期刊名：MATERIALS

收录：;EI(收录号：20193107261158);Scopus(收录号：2-s2.0-85069922578);WOS:【SCI-EXPANDED(收录号:WOS:000471012500123)】；

基金：This research was funded by National Natural Science Foundation of China, grant number 31770610, and National Non-profit Special Fund for Fundamental Research from Chinese Academy of Forestry, grant number CAFYBB2017ZX003.

语种：英文

外文关键词：lignin; nanoparticles; vehicles; structure; doxorubicin

摘要：Because of their exceptional absorption capacity, biodegradability, and nontoxicity, nanomaterials fabricated from renewable natural resources have recently become an increasingly important research area. However, the mechanism of drug encapsulation by lignin nanoparticles and the role of nanoparticle structure on the stability and loading performance still remain unknown. Herein, lignin hollow nanoparticles (LHNPs) were prepared and applied as promising vehicles for the antineoplastic antibiotic drug doxorubicin hydrochloride (DOX). The hydrogen bonding and - interactions contributed to the encapsulation of hydrophilic DOX by LHNPs with hydrophobic cavities. The encapsulation of DOX was enhanced by the pore volume and surface area. In addition, the nanoparticles contributed to the cellular uptake and the accumulation of the drug within HeLa cells. This work provides a scientific basis for future studies on the selective entrapment properties of hollow polymer nanoparticles derived from biomass material as vehicles for overcoming pharmacokinetic limitations.