文献类型：期刊文献

英文题名：Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)

作者：Lu, Keyang[1] Zhang, Yisheng[1,2] Li, Li[3,4] Wang, Xuewei[5] Ding, Gang[6,7]

第一作者：Lu, Keyang

通信作者：Zhang, YS[1]

机构：[1]Chinese Acad Forestry, Res Inst Wood Ind, Key Lab Wood Sci & Technol State Forestry Adm, Beijing 100091, Peoples R China;[2]Beijing Forestry Univ, Sch Technol, Beijing 100091, Peoples R China;[3]Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China;[4]Peking Union Med Coll, Beijing 100050, Peoples R China;[5]Chinese Acad Sci, Inst Microbiol, State Key Lab Systemat Mycol & Lichenol, Beijing 100080, Peoples R China;[6]Chinese Acad Med Sci, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100193, Peoples R China;[7]Peking Union Med Coll, Beijing 100193, Peoples R China

年份：2013

卷号：18

期号：9

起止页码：10944-10952

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000330306600056)】；

基金：We gratefully acknowledge financial support from the industry special fund project (201104004) and Research fund for central public research institute (CAFINT2013C10) for supporting this paper.

语种：英文

外文关键词：Chaetomium indicum; polyketides; chaetochromones; plant pathogens; wood decay

摘要：Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochromones A (1) and B (2) are a member of the polyketides family, which might originate from a similar biogenetic pathway as the known compounds PI-3 (3), PI-4 (4) and SB236050 (5). The biological activities of these secondary metabolites were evaluated against eight plant pathogens, including Alternaria alternata, Ilyonectria radicicola, Trichoderma viride pers, Aspergillus niger, Fusarium verticillioide, Irpex lacteus (Fr.), Poria placenta (Fr.) Cooke and Coriolus versicolor (L.) Quel. Compound 1 displayed moderate inhibitory rate (>60%) against the brown rot fungus Poria placenta (Fr.) Cooke, which causes significant wood decay. In addition, the cytotoxic activities against three cancer cell lines A549, MDA-MB-231, PANC-1 were also tested, without any inhibitory activities being detected.