文献类型：期刊文献

英文题名：An injectable self-healing hydrogel-cellulose nanocrystals conjugate with excellent mechanical strength and good biocompatibility

作者：Du, WenBo[1,2] Deng, Amin[1,2] Guo, Juan[4] Chen, Jian[3] Li, Huaming[1,2] Gao, Yong[1,2,3]

第一作者：Du, WenBo

通信作者：Gao, Y[1];Gao, Y[2]

机构：[1]Xiangtan Univ, Coll Chem, Xiangtan 411105, Hunan, Peoples R China;[2]Xiangtan Univ, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Hunan, Peoples R China;[3]Hunan Univ Sci & Technol, Hunan Prov Key Lab Controllable Preparat,Funct Ap, Sch Chem & Chem Engn,Hunan Prov Coll,Key Lab QSAR, Key Lab Theoret Organ Chem,Funct Mol Minist Educ, Xiangtan 411201, Hunan, Peoples R China;[4]Chinese Acad Forestry, Res Inst Wood Ind, Dept Wood Anat & Utilizat, Beijing 100091, Peoples R China

年份：2019

卷号：223

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20193007220983);Scopus(收录号：2-s2.0-85069571707);WOS:【SCI-EXPANDED(收录号:WOS:000481570700003)】；

基金：The authors appreciated the financial supports from the National Natural Science Foundation of China (21574112), and a project of Research Institute for Forestry New Technology, Chinese Academy of Forestry (No. CAFINT2014K03), the National Nonprofit Institute Research Grant of CAFINT. The authors also appreciated Dr. Yi Cao of Xiangtan University for in vitro cytotoxicity tests of nanocomposite hydrogel.

语种：英文

外文关键词：Cellulose nanocrystals (CNCs); Graft; Nanocomposite hydrogel; Reversible covalent bond; Self-healing

摘要：In this work, a novel strategy for the construction of injectable self-healing nanocomposite (NC) hydrogels dominated by reversible boronic ester bonds was demonstrated. Specifically, NC hydrogels were constructed by the solution-mixing of N, N-dimethylacrylamide-stat-3-acrylamidophenylboronicacid statistical copolymers (PDMA-stat-PAPBA) and poly(glycerolmonomethacrylate) (PGMA) chains grafted cellulose nanocrystals (CNC-g-PGMA). Rheology analysis indicated the as-constructed NC hydrogel displayed about 7-fold increase in the storage modulus with a low CNCs loading level of 1.43 wt% in comparison with PGMA/PDMA-stat-PAPBA hydrogel without CNCs. Furthermore, the mechanical strength of the CNC-g-PGMA/PDMA-stat-PAPBA hydrogel was far superior to that of its PGMA/PDMA-stat-PAPBA/CNCs hydrogel counterpart, in which PGMA chains were not covalently grafted on the surfaces of CNCs. Due to reversible boronic ester bonds cross-linking networks, CNC-g-PGMA/PDMA-stat-PAPBA NC hydrogel exhibited excellent self-healing and injectable properties as well as pH/glucose responsive sol-gel transitions. Good biocompatibility was also demonstrated through in vitro cytotoxicity tests.