文献类型：期刊文献

英文题名：Novel diaminomaleonitrile-based fluorescent probe for ratiometric detection and bioimaging of hypochlorite

作者：Jiang, Yuliang[1] Wu, Shishan[3] Jin, Can[2] Wang, Bingxiang[1] Shen, Jian[1,3]

第一作者：Jiang, Yuliang

通信作者：Wang, BX[1]

机构：[1]Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China;[2]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China;[3]Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

年份：2018

卷号：265

起止页码：365-370

外文期刊名：SENSORS AND ACTUATORS B-CHEMICAL

收录：;EI(收录号：20181204934130);Scopus(收录号：2-s2.0-85044131856);WOS:【SCI-EXPANDED(收录号:WOS:000430232500044)】；

基金：This work was supported by the China Postdoctoral Fund Surface Project (2017M610335), National Natural Science Foundation of China (No. 31400516) and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

语种：英文

外文关键词：Hypochlorous acid; Ratiometric Fluorescence; Colorimetric fluorescent; Cell imaging

摘要：Highly sensitive and selective detection for hypochlorite anion (OCl-) is of extreme significance due to its important role and function in biological systems. Herein, a diaminomaleonitrile derivative (DMD) has been developed as a novel ratiometric and colorimetric fluorescent probe for OCl- detection. Consistent with the UV-vis spectral change, the probe DMD exhibited promptly a color change from canary yellow to gules upon the addition of OCl-, which could be easily observed by naked-eyes. In addition, the detection limit was found to be 0.5 nM, which is much lower than that of many reported OCl- probes. More importantly, owing to its excellent sensing properties and negligible cytotoxicity, probe DMD can be conveniently applied to image intracellular OCl- in living cells, indicating it a promising tool in biological applications. (C) 2018 Elsevier B.V. All rights reserved.