文献类型：期刊文献

中文题名：植物单宁构筑的水凝胶材料及其生物医药应用

英文题名：Plant Tannin-based Hydrogel Materials and Their Biomedical Applications

作者：胡新宇[1]

第一作者：胡新宇

机构：[1]中国林业科学研究院林产化学工业研究所、江苏省生物质能源与材料重点实验室、国家林业和草原局林产化学工程重点实验室、林木生物质低碳高效利用国家工程研究中心、江苏省林业资源高效加工利用协同创新中心,江苏南京210042

年份：2023

卷号：57

期号：4

起止页码：1-16

中文期刊名：生物质化学工程

外文期刊名：Biomass Chemical Engineering

收录：CSTPCD

基金：中国林业科学研究院优秀青年创新人才项目(CAFYBB2020QB007);江苏省生物质能源与材料重点实验室基本科研业务费(JSBEM-S-202209)。

语种：中文

中文关键词：植物单宁;水凝胶材料;组织工程;药物输送;伤口敷料

外文关键词：plant tannin;hydrogel material;tissue engineering;drug delivery;wound dressing

分类号：TQ35

摘要：植物单宁在自然界中的储量非常丰富,其分子结构中含有的大量酚羟基易于化学修饰;同时,单宁具有较强的抗氧化、抗病毒和抗肿瘤等生物活性,对细菌和酶具有显著的抑制作用。为研究植物单宁在生物医药材料领域的利用范围,本文综述了单宁基水凝胶的研究进展及其在组织工程、药物输送和伤口敷料领域的潜在应用,并对材料的工业化制备方法进行了总结与概括。首先详细介绍了不同类型单宁基水凝胶的设计策略和形成机理,特别对单宁的分子结构、生化特性在水凝胶构筑过程中所起的作用进行了深入分析;然后对水凝胶的具体应用以及最新的研究热点进行了阐述;最后探讨了这类材料目前的局限性并对未来规模化的工业生产前景进行了展望。
Plant tannins were very rich in nature,and a large number of phenolic hydroxyl groups contained in their molecular structure were easy to be chemically modified.At the same time,tannins had strong antioxidant,antiviral,antitumor and other biological activities,and had a significant inhibitory effect on bacteria and enzymes.In order to study the application of plant tannins in the field of biomedical materials,this article reviewed the research progress of tannin-based hydrogels and their potential applications in the fields of tissue engineering,drug delivery,and wound dressing,and the industrial preparation methods of materials were also summarized.Firstly,the design strategies and formation mechanisms of different types of tanninbased hydrogels were introduced in detail.In particular,the role of molecular structure and biochemical properties of tannins in the construction process of hydrogels were analyzed deeply.The specific application of hydrogels and the latest research hotspots were then elaborated.Finally,the current limitations of these materials were discussed,and the prospects of large-scale industrial production in the future were highlighted.