文献类型：期刊文献

英文题名：gamma-Aminobutyric acid is closely associated with accumulation of flavonoids

作者：Xie, Tiantian[1] Ji, Jing[1] Chen, Wei[1] Yue, Jianyun[1] Du, Changjian[1] Sun, Jiacheng[1] Chen, Lanzhen[2,3] Jiang, Zeping[4] Shi, Shengqing[1]

第一作者：Xie, Tiantian

通信作者：Jiang, ZP[1];Shi, SQ[2]

机构：[1]Chinese Acad Forestry, State Key Lab Tree Genet & Breeding, Key Lab Tree Breeding & Cultivat State Forestry A, Res Inst Forestry, Beijing, Peoples R China;[2]Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China;[3]Minist Agr, Risk Assessment Lab Bee Prod Qual & Safety, Beijing, Peoples R China;[4]Chinese Acad Forestry, Res Inst Forest Ecol Environm & Protect, Key Lab Forest Ecol & Environm State Forestry Adm, Beijing, Peoples R China

年份：2019

卷号：14

期号：7

外文期刊名：PLANT SIGNALING & BEHAVIOR

收录：;Scopus(收录号：2-s2.0-85064669097);WOS:【SCI-EXPANDED(收录号:WOS:000465945300001)】；

基金：Fundamental Research Funds for the Central Non-profit Research Institution of CAF (CAFYBB2016SY002; CAFYBB2014ZX001-3), the National Natural Science Foundation of China (31100490), Fund Project of Science and Technology Activities for Overseas Students of the Ministry of Human Resources and Social Sciences Security of the People's Republic of China (2016).

语种：英文

外文关键词：GABA; phenylpropanoid pathway; flavonoids; carbon metabolism; poplar

摘要：gamma-Aminobutyric acid (GABA) is an important neurotransmitter in mammals whose receptor is reported to be regulated by flavonoids. In plants, it is considered to be at the intersection of carbon and nitrogen metabolism, but its relationship with flavonoid metabolism remains unclear. Our recent RNA-seq analysis showed that expression of flavonoid biosynthetic genes was influenced in poplar by the blockage of alpha-ketoglutarate dehydrogenase (alpha-KGDH) activity and the application of GABA under NaCl stress, accompanied by the changes in GABA shunt activity. Here, we further found that the flavonoid accumulation was significantly affected by blocking the activities of alpha-KGDH and GABA transaminase as well as applying exogenous GABA, coupled with the changes of endogenous GABA contents. Key genes involved in the flavonoid biosynthetic pathway were also significantly influenced, including two PALs, 4CL, and two CHSs. Our results suggest that the GABA shunt is closely associated with the metabolism of flavonoids, which would benefit future understanding of GABA's roles in carbon allocation by regulating the pathway of flavonoid biosynthesis under normal or stress conditions.