文献类型：期刊文献

英文题名：A novel signal-on fluorometric sensor based on metal ion-mediated carbon dots for formaldehyde determination and lysosome-targeted bioimaging

作者：Zhou, Xi[1,2,3] Hu, Yun[2,3] Cao, Yufeng[1] Liu, Yuan[1] Qian, Tao[1]

第一作者：Zhou, Xi

通信作者：Liu, Y[1];Qian, T[1]

机构：[1]Nantong Univ, Sch Chem & Chem Engn, Nantong 226019, Peoples R China;[2]Chinese Acad Forestry, Inst Chem Ind Forestry Prod, Nanjing 210042, Peoples R China;[3]Nanjing Forestry Univ, Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Nanjing 210037, Peoples R China

年份：2022

卷号：46

期号：36

起止页码：17540-17547

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：;EI(收录号：20223912797940);Scopus(收录号：2-s2.0-85138670191);WOS:【SCI-EXPANDED(收录号:WOS:000847752300001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (31890773, 31890770).

语种：英文

外文关键词：Carbon - Metal ions - Metals - Nitrogen - Signal to noise ratio - Silver nanoparticles - Sulfur

摘要：Formaldehyde (FA) can exist in living cells and is involved in many physiological processes within organelles, especially lysosome, which plays pivotal roles in the FA metabolism of living systems. Therefore, a technique for the rapid and effective detection of FA is in high demand. Herein, a novel signal-on fluorometric strategy for FA determination based on Ag+-mediated nitrogen-sulfur co-doped carbon dots (Ag-M-NSCDs) was developed. The FA-responsive sensor was facilely prepared through introducing Ag+ into the lignin-derived nitrogen-sulfur co-doped carbon dots (NSCDs), accompanied by fluorescence (FL) reduction. With the addition of the FA solution, the redox interaction between Ag+ and FA led to the generation of Ag nanoparticles (Ag NPs) and separation of Ag+ from the surface of NSCDs, both of which contributed to the remarkable FL recovery. Furthermore, the fluorometric sensing system can selectively and sensitively detect FA with a linear response in a concentration range of 0-500 mu M (R-2 = 0.997) and a low detection limit of 500 nM based on three times signal-to-noise criteria, which make the nanosensor favorable for monitoring FA in real water samples and live cells. Furthermore, it showed superior lysosomal targeting performance with a Pearson coefficient of 0.87, which demonstrates a new method for FA-related biological studies and bioanalysis.