文献类型：期刊文献

英文题名：Potential Mechanism of Detoxification of Cyanide Compounds by Gut Microbiomes of Bamboo-Eating Pandas

作者：Zhu, Lifeng[1,2] Yang, Zhisong[3] Yao, Ran[1] Xu, Liangliang[1] Chen, Hua[4] Gu, Xiaodong[5] Wu, Tonggui[6] Yang, Xuyu[5]

第一作者：Zhu, Lifeng

通信作者：Zhu, LF[1];Zhu, LF[2]

机构：[1]Nanjing Normal Univ, Coll Life Sci, Nanjing, Jiangsu, Peoples R China;[2]Univ Nebraska Omaha, Omaha, NE 68182 USA;[3]China West Normal Univ, Key Lab Southwest China Wildlife Resources Conser, Minist Educ, Nanchong, Peoples R China;[4]Shanghai Biozeron Bioinformat Ctr, Shanghai, Peoples R China;[5]Sichuan Stn Wildlife Survey & Management, Chengdu, Sichuan, Peoples R China;[6]Chinese Acad Forestry, Res Inst Subtrop Forestry, East China Coastal Forest Ecosyst Long Term Res S, Fuyang, Zhejiang, Peoples R China

年份：2018

卷号：3

期号：3

外文期刊名：MSPHERE

收录：;Scopus(收录号：2-s2.0-85055169181);WOS:【SCI-EXPANDED(收录号:WOS:000437234900032)】；

基金：This work was supported by grants from the National Science Fund for Outstanding Young Scholars of China (grant no. 31222009), National Natural Science Fund (grant no. 31570489), National Key Programme of Research and Development, Ministry of Science and Technology (grant no. 2016YFC0503200), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and the Reintroduction Program of Giant Pandas.

语种：英文

外文关键词：bamboo; comparative genomics; cyanide compound detoxification; gut microbial metagenomes; pandas

摘要：Gut microbes can enhance the ability of hosts to consume secondary plant compounds and, therefore, expand the dietary niche breadth of mammalian herbivores. The giant and red pandas are bamboo-eating specialists within the mammalian order Carnivora. Bamboo contains abundant plant secondary metabolites (e.g., cyanide-containing compounds). However, Carnivora species, including the giant panda, have deficient levels of rhodanese (one of the essential cyanide detoxification enzymes) in their tissues compared with the same tissues of herbivores. Here, we make a comparative analysis of 94 gut metagenomes, including 25 from bamboo-eating pandas (19 from giant pandas and 6 from red pandas), 30 from Pere David's deer, and 39 from published data for other mammals. The bamboo-eating pandas' gut microbiomes had some common features, such as high proportions of Pseudomonas bacteria. The results revealed that bamboo-eating pandas' gut microbiomes were significantly enriched in putative genes coding for enzymes related to cyanide degradation (e.g., rhodanese) compared with the gut microbiomes of typical herbivorous mammals, which might have coevolved with their special bamboo diets. The enrichment of putative cyanide-digesting gut microbes, in combination with adaptations related to morphology (e.g., pseudothumbs) and genomic signatures, show that the giant panda and red panda have evolved some common traits to adapt to their bamboo diet. IMPORTANCE The giant panda (Ailuropoda melanoleuca) and red panda (Ailurus fulgens), two obligate bamboo feeders, have distinct phylogenetic positions in the order Carnivora. Bamboo is extraordinarily rich in plant secondary metabolites, such as allied phenolic and polyphenolic compounds and even toxic cyanide compounds. Here, the enrichment of putative cyanide-digesting gut microbes, in combination with adaptations related to morphology (e.g., pseudothumbs) and genomic signatures, show that the giant panda and red panda have evolved some common traits to adapt to their bamboo diet. Thus, here is another story of diet-driven gut microbiota in nature.