文献类型：期刊文献

英文题名：Synthesis and antitumor activity of novel α-aminophosphonates from diterpenic dehydroabietylaminer

作者：Rao, Xiaoping[1] Song, Zhanqian[1] He, Ling[2]

第一作者：饶小平

通信作者：Song, Z.|[a0005299698a324a3132b]宋争;[a0005bb860932cc858426]宋争;

机构：[1] Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing 210042, China; [2] Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China

年份：2008

卷号：19

期号：5

起止页码：512-516

外文期刊名：Heteroatom Chemistry

收录：EI(收录号：20083011400607);Scopus(收录号：2-s2.0-47549102442)

语种：英文

外文关键词：Chemical engineering - Chemistry

摘要：A series of novel α-aminophosphonates were synthesized from diterpenic dehydroabietylamine, and their structures were characterized by IR,1H NMR, and31P NMR spectroscopy. Their antitumor activities against SMMC7721 liver cancer cells were evaluated by the MTT method. Compounds 4 and 6 exhibited higher activities even at very low concentrations, and the inhibition ratios reached 75% and 79% at 0.1 μM, respectively. The inhibition ratio of compound 9 reached 99% after 72-h incubation. α-Aminophosphonates with a fluorine atom and a nitro group fused to the benzene ring exhibited higher activities. ? 2008 Wiley Periodicals, Inc.