文献类型：期刊文献

英文题名：Surface modification of silicone elastomer with rosin acid-based quaternary ammonium salt for antimicrobial and biocompatible properties

作者：Li, Zhaoshuang[1] Liu, He[1] Xu, Xu[2] Ma, Lina[3] Shang, Shibin[1] Song, Zhanqian[1]

第一作者：Li, Zhaoshuang

通信作者：Liu, H[1];Song, ZQ[1];Ma, LN[2]|[a0005c3716bb5fed5ea85]宋湛谦;

机构：[1]Chinese Acad Forestry, Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Natl Engn Lab Biomass Chem Utilizat,Key Lab Chem, Key Lab Biomass Energy & Mat,Inst Chem Ind Forest, Nanjing 210042, Jiangsu, Peoples R China;[2]Nanjing Forestry Univ, Coll Chem Engn, Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Jiangsu Prov Key Lab Chem & Utilizat Agroforest B, Nanjing 210037, Jiangsu, Peoples R China;[3]Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China

年份：2020

卷号：189

外文期刊名：MATERIALS & DESIGN

收录：;EI(收录号：20200508103777);Scopus(收录号：2-s2.0-85078475181);WOS:【SCI-EXPANDED(收录号:WOS:000519813000044)】；

基金：The authors express their gratitude for financial support from the Foundation of Jiangsu Province Biomass Energy andMaterial Laboratory (JSBEM-S-201905) and National Natural Science Foundation of China (31570562).

语种：英文

外文关键词：Quaternary ammonium salt; Rosin acid; Antimicrobial coating; Healthcare; Biocompatibility

摘要：Despite advanced sterilized and aseptic techniques, biomaterial-associated infections are still posing a great threat to human life. Therefore, constructing antimicrobial coating that exerts potent antimicrobial activity combined with low cytotoxicity is of great significance. Herein, an antimicrobial coating on the surface of silicone elastomer (PDMS) has been successful constructed, which based on maleopimaric acid quaternary ammonium cation (MPA-N+). The surface morphology and chemical composition of modified PDMS (PDMS-g-MPA-N+) were confirmed by scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), and X-ray photoelectron spectroscopy (XPS). The PDMS-g-MPA-N+ possess excellent antimicrobial activity against both Grampositive bacterial (Staphylococcus aureus) and Gram-negative bacterial (Escherichia coil, Pseudomonas aeruginosa) strains. In addition confocal laser scanning microscopy imaging demonstrated that it also can effectively inhibit bacterial biofilm formation over 5 days. Most importantly, PDMS-g-MPA-N+ exhibited excellent biocompatibility, which induced no significant hemolysis and cytotoxicity toward mammalian cells. The study demonstrated that the silicone elastomer surface grafted with MPA-N+ enabled the incorporation of a renewable biomass to effectively combat bacteria and biofilm formation for biomedical applications. (C) 2020 The Authors. Published by Elsevier Ltd.