文献类型：期刊文献

英文题名：Facile synthesis and antioxidant activity of lignin-related imidazo[1,2-a]pyridine derivatives

作者：Yang, Xiaohui[1,2] Shang, Qianqian[2] Bo, Caiying[2] Hu, Lihong[2] Zhou, Yonghong[1,2]

第一作者：杨晓慧

通信作者：Shang, QQ[1]

机构：[1]Chinese Acad Forest, Res Inst Forestry New Technol, Dongxiaofu 1 Xiangshan Rd, Beijing 100091, Peoples R China;[2]China Acad Forestry, Inst Chem Ind Forest Prod, Key Lab Biomass Energy & Mat, Nanjing 210042, Jiangsu, Peoples R China

年份：2018

卷号：2018

期号：5

起止页码：184-193

外文期刊名：ARKIVOC

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000456008800017)】；

基金：The authors are grateful for Fundamental Research Funds of Research Institute of Forestry New Technology, Grant. No. CAFYBB2016SY027 and Fundamental Research Funds from Jiangsu Province Biomass and Materials Laboratory, Grant. No. JSBEM-S-201803.

语种：英文

外文关键词：Lignin; Imidazo[1,2-a]pyridine; Multi-component reactions; Antioxidant activity

摘要：A convenient protocol is described for the preparation of lignin related imidazo[1,2-a] pyridine derivatives via three-component reactions among 2-aminopyridines, isocyanides and aromatic aldehydes obtained from lignin with excellent yields. Their in vitro antioxidant effects were evaluated by scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. The structure activity relationship (SAR) studies presented that the introduction of electron-donating group in imidazo[1,2-a]pyridine could increase the radical scavenging activity; On the contrary, the presence of electron-withdrawing might decrease the radical scavenging activity. In addition, cyclopentyl and cyclohexyl groups almost had the same influence on the antioxidant activity. Furthermore, the methoxy moiety had a significant impact on antioxidant capability, and hence syringyl imidazo[1,2-a]pyridines a, d, g, j and m exhibited excellent antioxidant properties [GRAPHICS] .