文献类型：期刊文献

中文题名：由松香合成氨基噻二唑衍生物及其抑菌活性

英文题名：Synthesis and Antibacterial Activity of Amino Thiadiazole from Rosin

作者：崔艳杰[1,2,3,4] 饶小平[1,2,3,4,5] 商士斌[1,2,3,4,5] 王娟[1,2,3,4]

第一作者：崔艳杰

机构：[1]中国林业科学研究院林产化学工业研究所;[2]江苏省生物质能源与材料重点实验室;[3]国家林业局林产化学工程重点开放性实验室;[4]生物质化学利用国家工程实验室;[5]中国林业科学研究院林业新技术研究所

年份：2013

卷号：30

期号：6

起止页码：712-715

中文期刊名：精细化工

外文期刊名：Fine Chemicals

收录：CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：江苏省自然科学基金项目(BK2011112)~~

语种：中文

中文关键词：松香;氨基噻二唑;抑菌活性;最低抑菌浓度;精细化工中间体

外文关键词：rosin ; amino thiadiazole containing rosin group ; antibacterial activity ; minimum inhibitionconcentration ;fine chemical intermediates

分类号：TQ351.47

摘要：以松香为起始原料,经歧化、提纯得脱氢枞酸、二氢枞酸;经Diels-Alder双烯加成得丙烯海松酸和马来海松酸。4种酸与硫代氨基脲关环得到4个新型氨基噻二唑衍生物化合物。通过红外、MS、1HNMR和元素分析对产物进行了表征。采用最低抑菌浓度法对目标产物的抑菌性能进行了测试,初步的结果显示,化合物都有一定的抑菌活性,特别是化合物5-脱氢枞基-2-氨基-1,3,4-噻二唑对金黄色葡萄球菌和表皮葡萄球菌具有良好的活性,对其最低抑菌质量浓度均为4 mg/L,而且比脱氢枞酸的活性高。
Dehydroabietic and dihydroabietic acids were obtained from rosin through disproportionated reaction and purification. Aerylopimaric and maleopimaric acids were synthesized by Diels-Alder dienes addition with rosin as the starting material. Four novel amino thiadiazoles were synthesized from four kinds of acids and thiosemicarbazide through cyclization reaction. Their structures were characterized by means of IR, ^1 HNMR, MS, and elemental analysis. The bactericidal aetivitives of the total compounds were evaluated by the the minimum inhibition concentration. The preliminary results indicate that these compounds display extensive antibacterial activity. Compound 5-dehydroabietyl-2-amino-1, 3, 4- thiadiazole especially exhibit excellent antibacterial activity against Staphyloccocus aureu and Staphyloccocus epidermidis, with its minimum inhibition concentration of 4 mg/L, and its antibacterial activity is higher than that of dehydroabietic acid.