文献类型：期刊文献

英文题名：Production of Itaconic Acid Through Microbiological Fermentation of Inexpensive Materials

作者：Yang, Jing[1,2] Xu, Hao[1,2] Jiang, Jianchun[1,2] Zhang, Ning[1,2] Xie, Jingcong[1,2] Wei, Min[1,2] Zhao, Jian[1,2]

第一作者：杨静;Yang, Jing

机构：[1] Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, National Engineering Laboratory for Biomass Chemical Utilization, Key and Open Laboratory of Forest Chemical Engineering, State Forestry Administration, Key Laboratory of Biomass Energy and Material, Nanjing, Jiangsu Province, 210042, China; [2] Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing, 210037, China

年份：2019

卷号：4

期号：3

起止页码：135-142

外文期刊名：Journal of Bioresources and Bioproducts

收录：EI(收录号：20220411525788);Scopus(收录号：2-s2.0-85115841173)

语种：英文

外文关键词：Substrates - Genetic engineering - Aspergillus

摘要：Itaconic acid (IA) is a precursor of various chemicals, which has been on the US Department of Energy's list of the top 12 platform chemicals that can potentially be produced from biomass. The IA is mainly produced through a bio-fermentation method with sugar as raw material. However, the high cost and low yield restrict the industrial application of the IA. This review summarized research advances in the IA production from alternative substrates. In particular, the types of substrates as well as existing problems in the IA fermentation, strain breeding, and process regulation were discussed. And it is pointed that decreasing the price of the IA with alternative substrates and increasing the titer through genetic engineering should be further focused on to support the industrialization of the IA. ? 2019 Nanjing Forestry University