文献类型：期刊文献

中文题名：银杏叶聚戊烯醇金属配合物的合成及其光控活性

英文题名：Synthesis and Light-controlled Activity of Ginkgo biloba Leaves Polyprenols Metal Complex

作者：张昌伟[1,2] 陶冉[1] 齐志文[1] 沈红[1] 薛兴颖[1] 王成章[1,2]

第一作者：张昌伟

机构：[1]中国林业科学研究院林产化学工业研究所,生物质化学利用国家工程实验室,国家林业和草原局林产化学工程重点实验室,江苏省生物质能源和材料重点实验室,江苏南京210042;[2]中国林业科学研究院林业新技术研究所,北京100091

年份：2021

卷号：41

期号：2

起止页码：73-78

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：江苏省青年基金(BK20180152)。

语种：中文

中文关键词：银杏叶;聚戊烯醇;钌多吡啶;金属配合物;光控活性

外文关键词：Ginkgo biloba leaves;polyprenols;ruthenium polypyridine;metal complex;light-controlled activity

分类号：TQ35

摘要：以银杏叶聚戊烯醇(GBP)为原料,通过化学改性手段将其末端羟基替换成氰基,之后将氰基聚戊烯醇与钌多吡啶配合物络合,合成了聚戊烯醇-钌多吡啶配合物,并对其进行表征,考察了配合物的脂水分配系数、光致配体解离能力和光控抗肿瘤活性。核磁共振表征结果表明,氰基聚戊烯醇和聚戊烯醇-钌多吡啶配合物成功合成。合成的配合物具有较好的脂水分配系数(1.35),有利于其穿透细胞膜。此外,合成的配合物在光照下逐渐发生配体解离,在光照条件下,其对A549肿瘤细胞的半数抑制浓度(IC_(50))为29.3μmol/L,展示出比聚戊烯醇(IC_(50)=45.8μmol/L)更好的抗肿瘤活性,且配合物的光控抗肿瘤活性极可能与其DNA结合能力有关。
Ginkgo biloba leaves polyprenols(GBP)was used as raw material,and its terminal hydroxyl group was replaced with cyano group by chemical modification method.On this basis,cyano-GBP and ruthenium polypyridine complex were utilized as raw materials,the GBP-ruthenium polypyridine metal complex was synthesized and characterized by complex reaction.The lipid-water partition coefficient,photo-induced ligand dissociation ability and light-controlled antitumor activity of the complex were investigated.NMR results showed that the cyano-GBP and GBP-ruthenium polypyridine metal complex were successfully synthesized.The synthesized complex has good lipid-water partition coefficient(1.35),which was conducive to its penetration of cell membranes.In addition,cyano-GBP ligand of the synthesized complex gradually dissociated under light and exhibited better antitumor activity with the half inhibitory concentration(IC_(50))against A549 tumor cell of 29.3μmol/L than GBP(IC_(50)=45.8μmol/L).Moreover,The light-controlled antitumor activity of the complex may be related to its DNA binding ability.