文献类型：期刊文献

中文题名：银杏叶聚戊烯醇对荷瘤鼠生命延长率的研究

英文题名：Study on Effect of Polyprenols from Ginkgo biloba Linn. on Prolonging the Life of Cancer-bearing Mice

作者：王成章[1,2] 沈兆邦[1,2] 郑光耀[1,2] 叶建中[1,2] 周昊[1,2]

第一作者：王成章

机构：[1]中国林业科学研究院林产化学工业研究所;[2]国家林业局林产化学工程重点开放性实验室

年份：2007

卷号：27

期号：B10

起止页码：24-28

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;Scopus;CSCD:【CSCD_E2011_2012】；

基金：国家科技支撑计划项目资助(2006BAD06B09);国家林业局推广项目(2007-80)

语种：中文

中文关键词：银杏叶;聚戊烯醇;人脑瘤SF763;人肺腺瘤A549;艾氏腹水瘤EC;生命延长率

外文关键词：Ginkgo biloba Linn. ; polyprenols ; SF763 ; A549 ; EC ; life-prolonging rate

分类号：TQ91

摘要：以银杏叶为原料，采用皂化反应、溶剂冷冻和Ⅱ级分子蒸馏分离聚戊烯醇不皂化物，精制银杏叶聚戊烯醇（GP），纯度87．3％。通过建立人脑瘤SF763、人肺腺瘤A549和艾氏腹水瘤Ec移植小鼠模型，GP口服给药，研究GP对人脑瘤SF763裸鼠和艾氏腹水瘤Ec小鼠的生命延长率，观察GP对人肺腺瘤A549裸鼠的抑瘤率。结果表明：生药剂量320mg／kgGP联合2mg／kg阿霉素（ADM），其生命延长率为88％（P〈0．01），GP能明显延长荷人脑瘤SF763裸鼠生命；GP在大于40mg／kg时对人肺腺瘤A549裸鼠具有明显的抑制作用（P〈0．05），最佳剂量为GP80mg／kg，接种时间11d，抑瘤率为82．2％（P〈0．01）；GP对艾氏腹水瘤EC小鼠的生存期呈现负量效关系，GP最佳剂量范围在5-10mg／kg，最高生命延长率为32．77％（P〈0．05）。
Polyprenols from Ginkgo biloba Linn. （GP） was made to get a purify of 87.3 % by separating non-saponifialble matter of GP with means of saponification, solvent refrigeration and II-grade molecular distillation. Different models of mice planted with SF763 tumor, A549 tumor, and transplanted EC tumor respectively were built. The effects of GP on prolonging survival time of mice bearing tumors of SF763, A549 and Ec respectively were studied by treating with ADM and ACNU iv. , CY ip. and polyprenols po.. The results showed that GP （320 mg/kg） combined with ADM （2 mg/kg） could significantly prolong survival time of mice bearing SF763 tumor, the life-prolonging rate was 88 % （P 〈0.01 ）in contrast to normal controls; GP （ 〉40 mg/kg） significantly had a inhibition on A549 （P 〈 0.05 ）, the optium dosage of GP was 80 mg/kg, which had an inhibition of 82.2 % （P 〈0.01 ） after an inoculation of 11 days; GP had a negative relation on prolonging survival time of mice bearing EC tumors between dosage of GP and the effect. The optimum dosage was 5-10 mg/kg, which had optimum prolonging rate of 32.77 % （ P 〈 0.05 ）. Thus GP could significantly prolong survival time of mice bearing SF763, A549 and EC tumors.