文献类型：期刊文献

英文题名：Synthesis and biological activity of polyprenols

作者：Zhang, Qiong[1,2,3,4] Huang, Lixin[1,2,3] Zhang, Caihong[1,2,3] Xie, Pujun[1,2,3] Zhang, Yaolei[1,2,3] Ding, Shasha[1,2,3] Xu, Feng[4]

第一作者：Zhang, Qiong

通信作者：Huang, LX[1]|[a000570f79d3438a5c2bd]黄立新;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China;[2]SFA, Natl Engn Lab Biomass Chem Utilizat Key & Open La, Nanjing 210042, Jiangsu, Peoples R China;[3]Key Lab Biomass Energy & Mat, Nanjing 210042, Jiangsu, Peoples R China;[4]Beijing Forestry Univ, Beijing 100083, Peoples R China

年份：2015

卷号：106

起止页码：184-193

外文期刊名：FITOTERAPIA

收录：;Scopus(收录号：2-s2.0-84943172040);WOS:【SCI-EXPANDED(收录号:WOS:000363348200026)】；

基金：This study was financially supported by the programme of Three New of Jiangsu Forestry Bureau (No. LYSX[2014]09).

语种：英文

外文关键词：Polyprenyl; Derivatives; Dolichols; Biological activity

摘要：The polyprenols and their derivatives are highlighted in this study. These lipid linear polymers of isoprenoid residues are widespread in nature from bacteria to human cells. This review primarily presents the synthesis and biological activities of polyprenyl derivatives. Attention is focused on the synthesis and biological activity of dolichols, polyprenyl ester derivatives and polyprenyl amines. Other polyprenyl derivatives, such as oxides of polyprenols, aromatic polyprenols, polyprenyl bromide and polyprenyl sulphates, are mentioned. It is noted that polyprenyl phosphates and polyprenyl-linked glycosylation have better antibacterial, gene therapy and immunomodulating performance, whereas polyprenyl amines have better for antibacterial and antithrombotic activity. Dolichols, polyprenyl acetic esters, polyprenyl phosphates and polyprenyl-linked glycosylation have pharmacological anti-tumour effects. Finally, the postulated prospect of polyprenols and their derivatives are discussed. Further in vivo studies on the above derivatives are needed. The compatibility of polyprenols and their derivatives with other drugs should be studied, and new preparations of polyprenyl derivatives, such as hydrogel glue and release-controlled drugs, are suggested for future research and development. (C) 2015 Elsevier B.V. All rights reserved.