文献类型：期刊文献

英文题名：Urushiol-dextran SPIONs magnetic recyclable nanoparticles immobilizing vancomycin (V@DU@Fe) for antibacterial application

作者：Xue, Xingying[1,2,3] Qi, Zhiwen[1,3,4] Wang, Zhihong[5] Tao, Ran[1,3] Zhou, Hao[1,3] Chen, Hongxia[1,3] Lei, Jiandu[2] Wang, Chengzhang[1,3]

第一作者：Xue, Xingying;薛兴颖

通信作者：Qi, ZW[1]

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Natl Engn Lab Biomass Chem Utilizat, Nanjing 210042, Jiangsu, Peoples R China;[2]Beijing Forestry Univ, Coll Mat Sci & Technol, Beijing 100083, Peoples R China;[3]Chinese Acad Forestry, Key Lab Biomass Energy & Mat, Nanjing 210042, Jiangsu, Peoples R China;[4]Coinnovat Ctr Efficient Proc & Utilizat Forest Res, Nanjing 210042, Jiangsu, Peoples R China;[5]Guangdong Acad Forestry, Guangdong Prov Key Lab Silviculture Protect & Util, Guangzhou 510520, Peoples R China

年份：2025

卷号：304

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20250717875460);Scopus(收录号：2-s2.0-85217696521);WOS:【SCI-EXPANDED(收录号:WOS:001428152700001)】；

基金：The study was supported by the National Natural Science Foundation of China (grant 32101472) , and the Jiangsu Provincial Key Laboratory of Biomass Energy and Materials Basic Research Business Project (grant JSBEM-S-202315) .

语种：英文

外文关键词：Urushiol; Dextran; SPIONs; Vancomycin; Magnetic recycle; Antibacterial

摘要：In this study, magnetic nanocarriers (DU@Fe, Davg = 281.6 nm, zeta potential -28.0 mV) were fabricated using dextran, urushiol as the shell and superparamagnetic iron oxide nanoparticles (SPIONs) as the core. Subsequently, the specific ligand Lys-D-Ala-D-Ala of vancomycin (Van) was grafted onto the surface of DU@Fe, which generated nanoparticles (Lys-D-Ala-D-Ala@DU@Fe) with an average particle size of 385.5 nm and a zeta potential of -16.8 mV via specific and robust interaction. Ultimately, the immobilization capacity of Van reached up to 294.1 mg & sdot;g- 1 for efficient antibacterial properties. Moreover, the assembly process adhered to the pseudosecond-order kinetics model (R2 = 0.998-0.999) and the Langmuir adsorption isotherm model (R2 = 0.999, 30 degrees C). Notably, V@DU@Fe effectively adhered to the cell envelopes of both Gram-negative and Gram-positive bacteria, achieving rapid bactericidal effects within 1 h. Furthermore, it maintained over 85.0 % of its initial antibacterial efficiency against S. aureus and S. epidermidis even after six recycles. Therefore, this study provides strategies and methods for the development of urushiol-dextran intelligent SPIONs nanomedicines.