文献类型：期刊文献

英文题名：Formation of self-assembled polyelectrolyte complex hydrogel derived from salecan and chitosan for sustained release of Vitamin C

作者：Hu, Xinyu[1,2,3,4] Wang, Yongmei[1] Zhang, Liangliang[1] Xu, Man[1]

第一作者：Hu, Xinyu;胡新宇

通信作者：Hu, XY[1]|[a0005881e11db1c0efa81]胡新宇;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forestry Prod, Key Lab Biomass Energy & Mat, Nanjing 210042, Jiangsu, Peoples R China;[2]Co Innovat Ctr Efficient Proc & Utilizat Forest R, Nanjing 210042, Jiangsu, Peoples R China;[3]Natl Forestry & Grassland Adm, Key Lab Chem Engn Forest Prod, Beijing 100714, Peoples R China;[4]Natl Engn Lab Biomass Chem Utilizat, Nanjing 210042, Peoples R China

年份：2020

卷号：234

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20200608130231);Scopus(收录号：2-s2.0-85078837237);WOS:【SCI-EXPANDED(收录号:WOS:000513917300043)】；

基金：This work was supported by the Key Lab. of Biomass Energy and Material, Jiangsu Province (KLBEM) under the Grant JSBEM-S-201904 and the National Natural Science Foundation of China under the Grant 31700500.

语种：英文

外文关键词：Vitamin C protection; Polyelectrolyte complex hydrogel; Self-assembly; Salecan; Electrostatic interactions; pH-dependent release; Release mechanism

摘要：Vitamin C (VC) is an indispensable nutrient for human health. However, poor chemical stability in gastric environment restricts its full assimilation by intestine. It is important to construct a safe carrier that can protect VC from the gastric fluid and sustainably release it in intestine. Herein, we designed a novel polyelectrolyte complex (PEC) hydrogel through self-assembly of salecan and chitosan. PEC structure formed by electrostatic interactions was confirmed by FT-IR, XRD, XPS and TGA. Their swelling, morphology, rheology, cytocompatibility and biodegradation were well investigated. In particular, VC released in a controlled and pH-dependent manner. The release amount in simulated intestinal fluid (SIF) was significantly higher than simulated gastric fluid (SGF), and can be maintained at high level in blood after 6 h. Release mechanism agreed well with Ritger-Peppas model. The purpose of this study was to develop a smart nutrient delivery platform for targeted release of VC in intestinal condition.