文献类型：期刊文献

中文题名：分子印迹技术在分离天然活性成分中的应用研究进展

英文题名：Research Progress on the Application of Molecular Imprinting Technology in the Separation of Natural Active Ingredients

作者：管勤昊[1] 闫林林[1] 汤丽华[1] 徐曼[1] 张亮亮[2] 黄立新[1]

第一作者：管勤昊

机构：[1]中国林业科学研究院林产化学工业研究所,江苏省生物质能源与材料重点实验室,国家林业和草原局林产化学工程重点实验室,林木生物质低碳高效利用国家工程研究中心,江苏省林业资源高效加工利用协同创新中心,江苏南京210042;[2]华侨大学先进碳转化技术研究院,福建厦门361021

年份：2023

卷号：57

期号：5

起止页码：51-60

中文期刊名：生物质化学工程

外文期刊名：Biomass Chemical Engineering

收录：CSTPCD

基金：国家重点研发计划资助项目(2022YFD1300903);国家自然科学基金资助项目(31901236);华侨大学引进人才科研启动经费(22BS133)。

语种：中文

中文关键词：分子印迹技术;分子印迹聚合物;天然活性物质;天然产物化学

外文关键词：molecular imprinting technology;molecularly imprinted polymer;natural active substances;natural product chemisry

分类号：TQ35

摘要：分子印迹技术因具有特异识别性、高预选性和高稳定性等优点,在天然产物化学领域受到广泛关注,尤其是天然活性物质分离方面。本文对分子印迹技术的基本原理、结合方式、常用原料和聚合方法进行介绍,重点分析了分子印迹聚合物制备方法中的共价作用、非共价作用和金属配位作用等结合方式的区别与联系,同时讨论了2017~2022年分子印迹技术在分离黄酮类、多酚类、生物碱类、有机酸类、甾体类及其他天然活性成分的应用研究进展,并提出了目前分子印迹技术存在的问题和未来研究方向。
Molecular imprinting technology was the process of designing molecularly imprinted polymers against a target molecule as a template,and it had received a lot of attention in the direction of natural product chemistry,especially in the isolation of natural active substances,because of its advantages of specific recognition,high preselection and high stability.In this paper,we introduced the basic principles,binding modes,common raw materials and polymerization methods of molecular imprinting technology,focusing on the different connections of binding modes such as covalent interaction,non-covalent interaction and metal ligand interaction.At the same time,the applications of molecular imprinting technology in the separation of flavonoids,polyphenols,alkaloids,organic acids,steroids and other natural active ingredients in 2017-2022 were also discussed,and the current problems and future research directions of molecular blotting technology were proposed.