文献类型：期刊文献

中文题名：油橄榄羟基酪醇的生物合成及其衍生物研究进展

英文题名：Advance in Biosyntheses and Biological Activities of Olive Hydroxytyrosol and Its Derivatives

作者：原姣姣[1,2,3,4] 叶建中[1,2,3,4] 王成章[1,2,3,4,5] 鲁黎[6]

第一作者：原姣姣

通信作者：Wang, Cheng-Zhang

机构：[1]中国林业科学研究院林产化学工业研究所;[2]生物质化学利用国家工程实验室;[3]国家林业局林产化学工程重点开放性实验室;[4]江苏省生物质能源与材料重点实验室;[5]中国林业科学研究院林业新技术研究所;[6]湖北省林业科学研究院

年份：2015

卷号：35

期号：2

起止页码：154-162

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;EI(收录号：20151900826725);Scopus(收录号：2-s2.0-84929461082);北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：甘肃省科技重大专项(143NKDK025);国家林业局推广项目(2012-18)

语种：中文

中文关键词：羟基酪醇;羟基酪醇烷基醚;羟基酪醇糖苷;脂肪酸酯;生物转化

外文关键词：hydroxytyrosol; alkyl ether; lipophilic fatty acid ester; glucosylated derivatives; biological transformation

分类号：TQ35

摘要：介绍了传统化学合成羟基酪醇的方法,针对化学合成反应步骤多、催化剂昂贵、产率低、污染大等问题,重点总结了以橄榄苦苷和酪醇为原料生物法合成羟基酪醇的途径,同时还综述了羟基酪醇烷基醚、脂肪酸酯、糖基化等衍生物的制备方法、生物活性及其构效关系,为羟基酪醇及其衍生物批量制备及其抗肿瘤、抗癌、心脑血管疾病新药的筛选提供参考和指导作用。
Chemical syntheses of hydroxytyrosol from different materials were investigated. Its disadvantages included long route, the low yield of product, and expensive catalyst as well as toxic reactants, etc.. This paper emphatically summarized biological synthetic routes for hydroxytyrosol with oleuropein and tyrosol. Furthermore, the syntheses and biological activities of hydroxytyrosol alkyl ether, lipophilic fatty acid ester, and glueoside derivatives, and structure-activity relationship were introduced. It is important to further study the syntheses of hydroxytyrosol and derivatives, and exploit new medicine of anti- tumor, anticancer, cardiovascular and cerehrovascular diseases.