文献类型：期刊文献

英文题名：Construction of self-assembled polyelectrolyte complex hydrogel based on oppositely charged polysaccharides for sustained delivery of green tea polyphenols

作者：Hu, Xinyu[1,2,3,4] Wang, Yongmei[1] Zhang, Liangliang[1] Xu, Man[1]

第一作者：Hu, Xinyu;胡新宇

通信作者：Hu, XY[1]|[a0005881e11db1c0efa81]胡新宇;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forestry Prod, Key Lab Biomass Energy & Mat, Nanjing 210042, Jiangsu, Peoples R China;[2]Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Nanjing 210042, Jiangsu, Peoples R China;[3]Natl Forestry & Grassland Adm, Key Lab Chem Engn Forest Prod, Beijing 100714, Peoples R China;[4]Natl Engn Lab Biomass Chem Utilizat, Nanjing 210042, Jiangsu, Peoples R China

年份：2020

卷号：306

外文期刊名：FOOD CHEMISTRY

收录：;EI(收录号：20194107518540);Scopus(收录号：2-s2.0-85072962905);WOS:【SCI-EXPANDED(收录号:WOS:000493282300033)】；

基金：This work was supported by the Key Lab. of Biomass Energy and Material, Jiangsu Province (KLBEM) under the Grant JSBEM-S-201904 and the National Natural Science Foundation of China under the Grant 31700500.

语种：英文

外文关键词：Polyelectrolyte complex hydrogel; Self-assembly; Food-grade polysaccharides; Green tea polyphenols; pH-dependent release; Release mechanism; Targeted nutrient delivery

摘要：In this study, we have developed a novel polyelectrolyte complex (PEC) hydrogel that could be easily prepared by self-assembly of two food-grade polysaccharides salecan and N,N,N-trimethyl chitosan (TMC). The electrostatic interactions between two polysaccharides were driving force in complexation processes and have been demonstrated by FTIR, XRD, XPS and TGA. The swelling capacity, morphology and rheological property of the hydrogels could be well tuned by controlling salecan/TMC ratio. Green tea polyphenols (GTP) was efficiently encapsulated into PEC hydrogels and liberated in a sustained pattern. The amount of GTP released in simulated intestinal fluid (SIF) was significantly higher than simulated gastric fluid (SGF). Increasing salecan/TMC ratio also markedly enhanced GTP release amount. Release exponent n obtained in SGF indicated a Fickian diffusion, while in SIF an anomalous transport occurred. The release mechanism was well-fitted with Ritger-Peppas model. Taken together, these PEC hydrogels could be suitable carriers for intestinal targeted nutrient delivery.