文献类型：期刊文献

中文题名：银杏叶聚戊烯醇联合化疗肿瘤的药效研究

英文题名：PHARMACOLOGY OF POLYPRENOLS FROM GINKGO BILOBA L.LEAVES IN COMBINATION WITH CHEMOTHERAPEUTIC DRUGS ON TUMOR

作者：王成章[1] 沈兆邦[1] 高凌[2]

第一作者：王成章

通信作者：Wang, C.-Z.

机构：[1]中国林业科学研究院林产化学工业研究所;[2]江苏省肿瘤防治研究所

年份：2003

卷号：23

期号：3

起止页码：15-18

中文期刊名：林产化学与工业

外文期刊名：Chemistry & Industry of Forest Products

收录：CSTPCD;;EI(收录号：2004078020822);Scopus(收录号：2-s2.0-0742266864);CSCD:【CSCD_E2011_2012】；

基金：中国林科院重点资助项目(0189106)

语种：中文

中文关键词：银杏叶;聚戊烯醇;联合化疗;S180;肿瘤;药效;辅助化疗

外文关键词：Ginkgo biloba L.leaves; polyprenols; tumor; subsidiary chemotherapy; S_(180)

分类号：R730.53;R730.52

摘要：　研究了银杏叶聚戊烯醇(GP)联合化疗S180肿瘤的药效作用。从银杏叶中分离纯化聚戊烯醇,分别与阿霉素注射液(ADM)、氟脲嘧啶(5 Fu)、环磷酰胺(CTX)和顺铂(PDD)等化疗药联合用药,对S180荷瘤小鼠进行抑瘤实验,并与ADM、5 Fu、CTX和PDD单独用药比较。研究表明,聚戊烯醇与CTX、PDD、5 Fu联合化疗,对S180的抑瘤率分别从59.81%、43.06%、42.03%提高到70.56%、60.29%、63.45%;与ADM联合化疗,可使1.0mg/kg的ADM对S180的抑瘤率从50.93%提高到77.19%。研究结果表明,银杏叶聚戊烯醇具有明显的辅助化疗和减毒增效作用。
Pharmacology of polyprenols from Ginkgo biloba L.leaves(GP) in combination with chemotherapeutic drugs on tumor was studied.Polyprenols separated and purified from G.biloba L.leaves were administered in combination with adriamycin(ADM),5flauouracil(5Fu),cyclophosphamide(CTX) and cisplatin(PDD) respectively,in contrasting with ADM,5Fu,CTX and PDD alone.Experiments were carried out on mouse with transplanted S180.Results show that for polyprenols in combination with CTX,PDD and 5Fu,the inhibition of S180 nodule was raised from 59.81%,43.06% and 42.03% to 70.56%,60.29% and 63.45% respectively,in contrasting with their administration alone.For ADM in combination with polyprenols,1.0 mg/kg ADM had raised the inhibition of S180 nodule from 50.93% to 77.19%.Results showed that polyprenols have a significant subsidiary effect on chemotherapy,along with reduced toxicity.