文献类型：期刊文献

中文题名：植物聚戊烯醇的化学修饰及药用剂型的研究进展

英文题名：Review on Structure Modification and Pharmaceutical Formulations of Plant Ployprenol

作者：袁花[1,2] 沈红[1,2] 颜洋洋[1,2] 张昌伟[1] 王成章[1]

第一作者：袁花

机构：[1]中国林业科学研究院林产化学工业研究所,江苏省生物质能源与材料重点实验室,国家林业和草原局林产化学工程重点开放性实验室,林木生物质低碳高效利用国家工程研究中心,江苏南京210042;[2]南京林业大学江苏省林业资源高效加工利用协同创新中心,江苏南京210037

年份：2022

卷号：42

期号：5

起止页码：137-146

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金资助项目(32101473);中国林科院中央级公益性科研院所基本科研业务费专项资金(CAFYBB2020SY039);江苏省生物质能源与材料重点实验室基本科研业务费项目(JSBEM-S-202008)。

语种：中文

中文关键词：植物聚戊烯醇;聚戊烯醇衍生物;结构修饰;药理活性

外文关键词：plant ployprenol;ployprenol derivatives;structural modification;pharmacological activity

分类号：TQ35

摘要：植物聚戊烯醇是一类天然的类酯化合物,具有抗癌、保肝以及抗病毒等良好的生物活性。但由于聚戊烯醇疏水性较强,导致其在人体内的生物利用度低。针对植物聚戊烯醇含有多个非共轭双键和末端羟基结构特征,总结了聚戊烯醇加氢、氧化、酯化、胺化、烷基化以及格式反应等化学修饰的研究进展,介绍了具有代表性的系列聚戊烯醇衍生物及其生物活性,并重点综述了基于植物聚戊烯醇及其衍生物设计的纳米乳液、脂质体和注射剂等药用剂型最新进展,为进一步研究聚戊烯醇及其衍生物的药品开发提供参考。
Plant polyprenols were a class of natural compound of esters with good biological activity, such as anticancer, hepatoprotective and antiviral. However, the strong hydrophobic of polyprenols resulted in the low bioavailability in the human body. In view of the structural characteristics of plant polyprenols containing multiple unconjugated double bonds and terminal hydroxyl groups, the research progress of polyprenols chemical modifications, such as addition, oxidation, esterification, amination, alkylation and grignard reaction were summarized, and a series of representative polyprenols derivatives and their biological activities were introduced. Meanwhile, the latest design and development of nanoemulsions, liposomes and injections based on plant polyprenols and their derivatives were reviewed, which provide a reference for further research into the development of pharmaceutical drugs of polyprenols and their derivatives.