文献类型：期刊文献

英文题名：Lutein-Based pH and Photo Dual-Responsive Novel Liposomes Coated with Ce6 and PTX for Tumor Therapy

作者：Shen, Hong[1,2,3] Zhang, Changwei[1,3] Wang, Chengzhang[1,3] Jiang, Jianxin[2] Tang, Fengxia[1,2] Li, Chuan[1] Yuan, Hua[1] Yang, Xiaoran[1] Tong, Zhenkai[1] Huang, Yi[4]

第一作者：Shen, Hong

通信作者：Wang, CZ[1];Wang, CZ[2]

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Chem Engn Forest Prod, Nanjing 210042, Peoples R China;[2]Beijing Forestry Univ, Dept Chem & Chem Engn, Beijing 100083, Peoples R China;[3]Nanjing Forestry Univ, Coinnovat Ctr Efficient Proc & Utilizat Forest Res, Nanjing 210042, Peoples R China;[4]Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China

年份：2023

外文期刊名：ACS OMEGA

收录：;Scopus(收录号：2-s2.0-85169027677);WOS:【SCI-EXPANDED(收录号:WOS:001047831200001)】；

基金：The authors are grateful for the valuable suggestion of C.Z. and C.W. This research was funded by the National Natural Science Foundation of China (32101473) and National Key Research & Development Program of China (2022YFD2200605).

语种：英文

摘要：Liposomes are considered the best nanocarrier for deliveringcancerdrugs such as chlorin e6 (Ce6) and paclitaxel (PTX). However, thepoor stability and non-selectivity release of liposomes may severelylimit their further applications. In this study, based on the characteristicsof lutein (L) photo-response and orthoester (OE) acid-response, stableand dual-responsive liposomes (Dr-lips) have been prepared. The Dr-lipsexhibited a spherical shape with a uniform size of approximately 58.27nm. Moreover, they displayed a zeta potential ranging from -45.45to -28.25 mV and showed excellent storage stability, indicatingstable colloidal properties. Additionally, they achieved high drugencapsulation rates, with 92.27% for PTX and 90.34% for Ce6, respectively.Meanwhile, under near-infrared (NIR) light at 660 nm, Ce6 plays akey role in accelerating the photodegradation rate of lutein and PEG-OE-Lwhile also enhancing tissue penetration ability. Additionally, Dr-lipsloaded with Ce6 and PTX not only displayed excellent pH and photodual-responsiveness for targeted delivering and releasing but alsoshowed remarkable reactive oxygen species (ROS) generation capacityand impressive anti-tumor activity in vitro. Therefore, it providesa novel strategy for optimizing stability and enhancing their targeteddrug delivery of liposome.