文献类型：期刊文献

中文题名：橄榄油次生代谢产物oleocanthal的研究进展

英文题名：Research Progress on Olive Oil Secondary Metabolite of Oleocanthal

作者：李文君[1,2] 王成章[1] 雷建都[2] 唐凤霞[1,2] 裴东[3] 宋晓波[3]

第一作者：李文君

机构：[1]中国林业科学研究院林产化学工业研究所/江苏省生物质能源与材料重点实验室/国家林业和草原局林产化学工程重点实验室/林木生物质低碳高效利用国家工程研究中心/江苏省林业资源高效加工利用协同创新中心,江苏南京210042;[2]北京林业大学材料科学与技术学院,北京100083;[3]中国林业科学研究院林业研究所,北京110000

年份：2022

卷号：42

期号：6

起止页码：136-146

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：中国林科院中央级公益性科研院所基本科研业务费专项资金(CAFYBB2017ZA004-2);江苏省生物质能源与材料重点实验室基本科研业务费项目(JSBEM-S-201810)。

语种：中文

中文关键词：布洛芬;抗炎活性;癌症;神经保护;生物利用度

外文关键词：ibuprofen;anti-inflammatory activity;cancer;neuroprotection;bioavailability

分类号：TQ35;S71

摘要：Oleocanthal(OC)是橄榄油的次生代谢产物,是目前国外研究热点,而国内关注较少,相关研究基础薄弱,与国外差距明显。作为近年来发现的重要活性物质,OC具有比布洛芬更强的抗炎活性,对以炎症为起源的多种疾病具有预防和治疗作用,如风湿类疾病、癌症、心血管疾病、糖尿病等,同时其神经保护功能也促使OC可以抑制阿尔茨海默症和帕金森症等神经退行性疾病的发生。本综述重点对OC的抗炎活性、抗癌活性(包括黑色素瘤、多发性骨髓瘤、乳腺癌和结肠癌)、神经保护、心血管保护、糖尿病的预防和治疗作用等生物活性进行了深入介绍,也分析了当前比较高效的OC提取分离方法,包括液-液萃取分离法、高效逆流色谱提取法、高真空辅助提取法和离心分配色谱法,同时对影响OC含量的多种因素进行了综合讨论,并进一步探讨了OC在生物利用度方面的研究进展,最后对OC的未来研究进行了展望。
Oleocanthal(OC)is a secondary metabolite of olive oil.Currently,it has become one of the research hotspots in abroad,while domestic attention is less.The relevant research foundation is weaker in China,and the big gap with foreign countries is obvious.As an important active ingredient discovered in recent years,OC has a stronger anti-inflammatory activity than that of ibuprofen,and it had preventive and therapeutic effects on various diseases originating from inflammation,such as rheumatic diseases,cancer,cardiovascular diseases,diabetes,etc.At the same time,its excellent neuroprotective function also promote OC to inhibit the occurrence of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.This review focuses on an in-depth introduction to the biological activities including anti-inflammatory activity and anticancer activity(including melanoma,multiple myeloma,breast and colon cancer),neuroprotection,cardiovascular protection,and the prevention and therapeutic effects of diabetes,and the current efficient extraction and separation methods of OC were also analyzed,including liquid-liquid extraction separation method,high performance countercurrent chromatography extraction method,high vacuum assisted extraction method and centrifugal partition chromatography method.Meanwhile,different factors affecting OC contents were comprehensively discussed,and its research progress in bioavailability was explored.Finally,the future research of OC was prospected.