文献类型：期刊文献

中文题名：皂角刺化学组成及药理活性应用研究进展

英文题名：Research Progress on Chemical Constitutents and PharmacologicalActivities of Thorns of Gleditsia sinensis

作者：刘勇[1] 张彩虹[1] 谢普军[1] 邓叶俊[1] 黄立新[1]

第一作者：刘勇

机构：[1]中国林业科学研究院林产化学工业研究所,江苏省生物质能源与材料重点实验室,国家林业和草原局林产化学工程重点实验室,林木生物质低碳高效利用国家工程研究中心,江苏省林业资源高效加工利用协同创新中心,江苏南京210042

年份：2023

卷号：57

期号：2

起止页码：89-98

中文期刊名：生物质化学工程

外文期刊名：Biomass Chemical Engineering

收录：CSTPCD

基金：中国林科院中央级公益性科研院所基本业务费专项基金(CAFYBB2020SY036);国家自然科学基金资助项目(31800614)。

语种：中文

中文关键词：皂角刺;化学组成;药理活性

外文关键词：Gleditsia sinensis thorns;chemical compositions;pharmacological activities

分类号：TQ35;R284

摘要：皂角刺在我国分布广泛,常用于传统中药材配伍,但对其化学成分及药理活性研究较少,阻碍了其进一步开发与利用。本文综述了皂角刺中的皂苷、黄酮、三萜、甾醇、多酚、生物碱、香豆素、吲哚类等次生代谢产物,并介绍了皂角刺的抗肿瘤、抗菌、抗氧化、抗人体免疫缺陷病毒(HIV)、抗炎、治疗抑郁症、治疗前列腺增生、治疗内分泌失调和免疫调节等药理活性研究进展,为皂角刺的合理开发利用提供了理论和应用依据。
Gleditsia sinensis thorn(GST)is widely distributed in China,which is commonly used in traditional Chinese medicine compatibility.However,few studies on its chemical composition and pharmacological activity hindered its further development and utilization.Based on the review of secondary metabolites containing saponins,flavonoids,triterpenoids,sterols,polyphenols,alkaloids,coumarins,indoles in GST,the research further introduced research progress of pharmacological activities of GST,such as anti-tumor,anti-bacterial,anti-oxidation,anti Human Immunodificiency Virus,anti-inflammatory,treatment of depression,treatment of prostate hyperplasia,treatment of endocrine disorders and immune regulation,providing a theoretical and application basis for the rational development and utilization of GST.